RESEARCH ON VALUES OF SERUM ACTIVIN-A CONCENTRATION IN DIAGNOSIS OF ECTOPIC PREGNANCY

Abstract

SUMMARY Objectives: To determine values of serum Activin-A and β-hCG concentrations in diagnosis of ectopic pregnancy (EP). Subjects and methods: A cross-sectional study conducted on 351 cases who were followed EP at the National Hospital for Obstetric and Gynaecolocy, and Military Hospital 103 from 9/2017 - 11/2019. Results: There were 194 cases of EP and 157 cases of intrauterine pregnancy (IUP). Mean serum concentration of Activin-A, β-hCG in EP group (2,440.9 pg/mL; 3,161.5 mUI/mL) was lower compared to IUP group (11,770.8 pg/mL, 39,185.8 mUI/mL); the difference was statistically significant (p < 0.05). The cut-off threshold of Activin-A was 3,233.7 pg/mL; β-hCG was 4921.5 mUI/mL; differential diagnosis of Activin-A and β-hCG between EP and IUP group had sensitivity of 87.1% and 91.7%, respectively; specificity of 27.3% and 71.3%, respectively; the difference was statistically significant (p < 0.05). Conclusion: Concentration of serum Activin-A and β-hCG levels were significant in the differential diagnosis of EP and IUP.